Drug interactions
Hydrochlorothiazide-olmesartan + Indapamide
Severity: Moderate
Hydrochlorothiazide-olmesartan and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide is a thiazide-like diuretic, so combining it with hydrochlorothiazide duplicates diuretic therapy. This increases the risk of hypokalemia, hyponatremia, hypotension and renal impairment.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Indapamide belongs to Cardiovascular.
Why it happens
Additive thiazide-type diuretic effects on renal sodium and potassium excretion.
What to do
Avoid concurrent use of two thiazide-type diuretics where possible. If combined, monitor sodium, potassium, creatinine and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Indapamide
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Indapamide?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indapamide is a thiazide-like diuretic, so combining it with hydrochlorothiazide duplicates diuretic therapy. This increases the risk of hypokalemia, hyponatremia, hypotension and renal impairment.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two thiazide-type diuretics where possible. If combined, monitor sodium, potassium, creatinine and blood pressure.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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