Drug interactions
Hydrochlorothiazide-olmesartan + Insulin degludec / insulin aspart
Severity: Moderate
Hydrochlorothiazide-olmesartan and Insulin degludec / insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olmesartan may enhance insulin sensitivity and increase hypoglycemia risk, while hydrochlorothiazide can raise blood glucose and reduce insulin effectiveness. The net effect on glycemic control is variable and can shift when either drug is started or changed.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing effects on insulin sensitivity: ARB improvement versus thiazide-induced glucose intolerance, partly via hypokalemia.
What to do
Monitor blood glucose closely when starting, stopping or adjusting the antihypertensive. Adjust insulin dose according to readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Insulin degludec / insulin aspart?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olmesartan may enhance insulin sensitivity and increase hypoglycemia risk, while hydrochlorothiazide can raise blood glucose and reduce insulin effectiveness. The net effect on glycemic control is variable and can shift when either drug is started or changed.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Insulin degludec / insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting, stopping or adjusting the antihypertensive. Adjust insulin dose according to readings.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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