Drug interactions
Hydrochlorothiazide-olmesartan + Insulin lispro protamine / insulin lispro
Severity: Moderate
Hydrochlorothiazide-olmesartan and Insulin lispro protamine / insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers may improve insulin sensitivity and increase the glucose-lowering effect of insulin, with a risk of hypoglycemia. Hydrochlorothiazide can oppose this by raising glucose levels.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Insulin lispro protamine / insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ARB-related improvement in insulin sensitivity opposed by thiazide-induced glucose intolerance.
What to do
Monitor blood glucose more often when the antihypertensive is started or changed. Adjust insulin dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Insulin lispro protamine / insulin lispro?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Insulin lispro protamine / insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin receptor blockers may improve insulin sensitivity and increase the glucose-lowering effect of insulin, with a risk of hypoglycemia. Hydrochlorothiazide can oppose this by raising glucose levels.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Insulin lispro protamine / insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when the antihypertensive is started or changed. Adjust insulin dose accordingly.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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