Drug interactions
Hydrochlorothiazide-olmesartan + Insulin regular human
Severity: Moderate
Hydrochlorothiazide-olmesartan and Insulin regular human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olmesartan may improve insulin sensitivity and heighten the hypoglycemic effect of regular insulin. Hydrochlorothiazide can worsen glucose tolerance, so glycemic control may change in either direction.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Insulin regular human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ARB-related improvement in insulin sensitivity opposed by thiazide-induced glucose intolerance.
What to do
Increase glucose monitoring when the antihypertensive is started, stopped or adjusted. Titrate insulin dose to readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Insulin regular human?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Insulin regular human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olmesartan may improve insulin sensitivity and heighten the hypoglycemic effect of regular insulin. Hydrochlorothiazide can worsen glucose tolerance, so glycemic control may change in either direction.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Insulin regular human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase glucose monitoring when the antihypertensive is started, stopped or adjusted. Titrate insulin dose to readings.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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