Drug interactions
Hydrochlorothiazide-olmesartan + Maitake
Severity: Minor
Hydrochlorothiazide-olmesartan and Maitake: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maitake mushroom has been reported to lower blood pressure in animal and limited human data, and might add to the effect of the antihypertensive combination. The interaction is theoretical, with little clinical evidence.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Maitake have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive blood pressure lowering; mechanism is not well established.
What to do
Monitor blood pressure if maitake supplements are started or stopped. Adjust antihypertensive dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Maitake?
MediHelp rates the interaction as minor. Hydrochlorothiazide-olmesartan and Maitake have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Maitake mushroom has been reported to lower blood pressure in animal and limited human data, and might add to the effect of the antihypertensive combination. The interaction is theoretical, with little clinical evidence.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Maitake?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if maitake supplements are started or stopped. Adjust antihypertensive dose if hypotension occurs.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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