Drug interactions
Hydrochlorothiazide-olmesartan + Meclofenamate
Severity: Moderate
Hydrochlorothiazide-olmesartan and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate is an NSAID that reduces renal prostaglandin synthesis, which can blunt the antihypertensive and diuretic effects of the combination. Together with an ARB and thiazide, NSAIDs increase the risk of acute kidney injury, especially in dehydrated or older patients, and may cause hyperkalemia.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of vasodilatory renal prostaglandins reduces renal perfusion and sodium excretion, which with RAS blockade and diuretic therapy impairs renal function.
What to do
Use the lowest effective NSAID dose for the shortest time and keep patients hydrated. Monitor blood pressure, serum creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Meclofenamate?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamate is an NSAID that reduces renal prostaglandin synthesis, which can blunt the antihypertensive and diuretic effects of the combination. Together with an ARB and thiazide, NSAIDs increase the risk of acute kidney injury, especially in dehydrated or older patients, and may cause hyperkalemia.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time and keep patients hydrated. Monitor blood pressure, serum creatinine and potassium.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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