Drug interactions
Hydrochlorothiazide-olmesartan + Metaproterenol
Severity: Moderate
Hydrochlorothiazide-olmesartan and Metaproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metaproterenol, a beta-2 agonist, can lower serum potassium, and hydrochlorothiazide adds renal potassium loss. The resulting hypokalemia may provoke arrhythmias, particularly at high doses or in patients with heart disease.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from beta-2 mediated intracellular potassium shift and thiazide kaliuresis.
What to do
Monitor serum potassium when metaproterenol is used regularly or at high doses. Replace potassium if hypokalemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Metaproterenol?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metaproterenol, a beta-2 agonist, can lower serum potassium, and hydrochlorothiazide adds renal potassium loss. The resulting hypokalemia may provoke arrhythmias, particularly at high doses or in patients with heart disease.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Metaproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium when metaproterenol is used regularly or at high doses. Replace potassium if hypokalemia occurs.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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