Drug interactions
Hydrochlorothiazide-olmesartan + Metformin
Severity: Moderate
Hydrochlorothiazide-olmesartan and Metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise blood glucose and reduce the effectiveness of metformin. Diuretic-related volume depletion and reduced kidney function may also increase metformin exposure and the risk of lactic acidosis.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Metformin belongs to Endocrine.
Why it happens
Thiazide-related hyperglycemia opposes metformin, and renal tubular competition or reduced renal function may decrease metformin clearance.
What to do
Monitor glucose control and renal function (eGFR), and hold or reduce metformin if dehydration or significant renal decline occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Metformin
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Metformin?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide can raise blood glucose and reduce the effectiveness of metformin. Diuretic-related volume depletion and reduced kidney function may also increase metformin exposure and the risk of lactic acidosis.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose control and renal function (eGFR), and hold or reduce metformin if dehydration or significant renal decline occurs.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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