Drug interactions
Hydrochlorothiazide-olmesartan + Methyclothiazide
Severity: Moderate
Hydrochlorothiazide-olmesartan and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methyclothiazide is a second thiazide diuretic, so combining it with a product that already contains hydrochlorothiazide duplicates therapy. This adds to diuresis, volume depletion, hypokalemia, hyponatremia, hypotension and renal impairment without much extra antihypertensive benefit.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Therapeutic duplication of thiazide diuretics produces additive inhibition of renal sodium chloride reabsorption.
What to do
Avoid using two thiazides together and stop methyclothiazide unless there is a specific indication. If they are co-administered, check electrolytes, creatinine and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide-olmesartan and Methyclothiazide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Methyclothiazide?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methyclothiazide is a second thiazide diuretic, so combining it with a product that already contains hydrochlorothiazide duplicates therapy. This adds to diuresis, volume depletion, hypokalemia, hyponatremia, hypotension and renal impairment without much extra antihypertensive benefit.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two thiazides together and stop methyclothiazide unless there is a specific indication. If they are co-administered, check electrolytes, creatinine and blood pressure.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
