Drug interactions
Hydrochlorothiazide-olmesartan + Mycophenolate
Severity: Minor
Hydrochlorothiazide-olmesartan and Mycophenolate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may compete with mycophenolic acid glucuronide for renal tubular secretion. This could modestly raise exposure to mycophenolate metabolites, but the clinical significance is uncertain.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Mycophenolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular secretion via organic anion transporters may reduce clearance of mycophenolate metabolites.
What to do
No dose change is routinely needed. Monitor for mycophenolate adverse effects such as cytopenias and gastrointestinal symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Mycophenolate?
MediHelp rates the interaction as minor. Hydrochlorothiazide-olmesartan and Mycophenolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide may compete with mycophenolic acid glucuronide for renal tubular secretion. This could modestly raise exposure to mycophenolate metabolites, but the clinical significance is uncertain.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Mycophenolate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed. Monitor for mycophenolate adverse effects such as cytopenias and gastrointestinal symptoms.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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