Drug interactions
Hydrochlorothiazide-olmesartan + Nafcillin
Severity: Minor
Hydrochlorothiazide-olmesartan and Nafcillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are acids secreted by renal tubular transporters, so in theory they could compete for elimination. Any resulting rise in levels is likely small and rarely clinically important.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for tubular secretion by organic anion transporters.
What to do
No dose adjustment is usually required. Monitor clinical response and adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Nafcillin?
MediHelp rates the interaction as minor. Hydrochlorothiazide-olmesartan and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are acids secreted by renal tubular transporters, so in theory they could compete for elimination. Any resulting rise in levels is likely small and rarely clinically important.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Nafcillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required. Monitor clinical response and adverse effects.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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