Drug interactions
Hydrochlorothiazide-olmesartan + Nitroglycerin rectal
Severity: Moderate
Hydrochlorothiazide-olmesartan and Nitroglycerin rectal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitroglycerin is a vasodilator and combining it with olmesartan and hydrochlorothiazide may cause additive blood pressure lowering. Patients may develop dizziness, orthostatic hypotension or syncope, especially if volume depleted.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation and reduced volume or angiotensin effect produce pharmacodynamic hypotension.
What to do
Monitor blood pressure, especially on initiation or dose increases. Advise patients to rise slowly and reduce the dose of one agent if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Nitroglycerin rectal?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitroglycerin is a vasodilator and combining it with olmesartan and hydrochlorothiazide may cause additive blood pressure lowering. Patients may develop dizziness, orthostatic hypotension or syncope, especially if volume depleted.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Nitroglycerin rectal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, especially on initiation or dose increases. Advise patients to rise slowly and reduce the dose of one agent if symptomatic hypotension occurs.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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