Drug interactions
Hydrochlorothiazide-olmesartan + Noni juice
Severity: Moderate
Hydrochlorothiazide-olmesartan and Noni juice: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Noni juice has a high potassium content. Olmesartan reduces potassium excretion, so large amounts of noni juice may contribute to hyperkalemia, especially in renal impairment, while hydrochlorothiazide partly offsets this.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Noni juice can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Dietary potassium load combined with angiotensin receptor blocker-mediated potassium retention, partly offset by thiazide kaliuresis.
What to do
Avoid regular large intake of noni juice in patients with reduced kidney function, and monitor serum potassium if consumed regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Noni juice?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Noni juice can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Noni juice has a high potassium content. Olmesartan reduces potassium excretion, so large amounts of noni juice may contribute to hyperkalemia, especially in renal impairment, while hydrochlorothiazide partly offsets this.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Noni juice?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular large intake of noni juice in patients with reduced kidney function, and monitor serum potassium if consumed regularly.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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