Drug interactions
Hydrochlorothiazide-olmesartan + Norepinephrine
Severity: Moderate
Hydrochlorothiazide-olmesartan and Norepinephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Norepinephrine is a vasopressor given in critical care, and it opposes the antihypertensive effect of these drugs. Both norepinephrine and thiazides can lower potassium, though the potassium shift from norepinephrine is modest.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Norepinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Alpha-adrenergic vasoconstriction opposes the antihypertensive drugs, and beta-2 mediated cellular potassium uptake adds to thiazide potassium loss.
What to do
Monitor blood pressure and serum potassium during infusion. Consider withholding the oral antihypertensive combination while the patient is hemodynamically unstable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Norepinephrine?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Norepinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Norepinephrine is a vasopressor given in critical care, and it opposes the antihypertensive effect of these drugs. Both norepinephrine and thiazides can lower potassium, though the potassium shift from norepinephrine is modest.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Norepinephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum potassium during infusion. Consider withholding the oral antihypertensive combination while the patient is hemodynamically unstable.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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