Drug interactions
Hydrochlorothiazide-olmesartan + Olmesartan
Severity: Moderate
Hydrochlorothiazide-olmesartan and Olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination product already contains olmesartan, so adding olmesartan alone duplicates the angiotensin receptor blocker. This raises the risk of excessive blood pressure lowering, hyperkalemia and renal impairment.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Olmesartan belongs to Cardiovascular.
Why it happens
Therapeutic duplication leading to additive angiotensin II receptor blockade.
What to do
Avoid giving olmesartan separately with the fixed-dose combination and adjust to a single regimen. If dose changes are made, monitor blood pressure, serum potassium and creatinine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Olmesartan?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination product already contains olmesartan, so adding olmesartan alone duplicates the angiotensin receptor blocker. This raises the risk of excessive blood pressure lowering, hyperkalemia and renal impairment.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving olmesartan separately with the fixed-dose combination and adjust to a single regimen. If dose changes are made, monitor blood pressure, serum potassium and creatinine.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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