Drug interactions
Hydrochlorothiazide-olmesartan + Parecoxib
Severity: Moderate
Hydrochlorothiazide-olmesartan and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as parecoxib (via its active metabolite valdecoxib) can blunt the effect of ARBs and diuretics and, together with them, raise the risk of acute kidney injury, particularly in dehydrated or elderly patients. Hyperkalemia may also occur.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
COX-2 inhibition reduces renal prostaglandins, causing sodium retention and lowered glomerular perfusion when combined with ARB and diuretic.
What to do
Maintain hydration and monitor blood pressure, creatinine and potassium, especially when starting parecoxib. Use the lowest effective dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Parecoxib?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as parecoxib (via its active metabolite valdecoxib) can blunt the effect of ARBs and diuretics and, together with them, raise the risk of acute kidney injury, particularly in dehydrated or elderly patients. Hyperkalemia may also occur.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Maintain hydration and monitor blood pressure, creatinine and potassium, especially when starting parecoxib. Use the lowest effective dose for the shortest time.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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