Drug interactions
Hydrochlorothiazide-olmesartan + Penicillin vk
Severity: Minor
Hydrochlorothiazide-olmesartan and Penicillin vk: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both penicillin and thiazides are secreted by renal tubular organic anion transport, so thiazides could slightly reduce penicillin clearance. The effect is small and rarely matters clinically.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Penicillin vk have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular anionic secretion.
What to do
No action is generally required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Penicillin vk?
MediHelp rates the interaction as minor. Hydrochlorothiazide-olmesartan and Penicillin vk have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both penicillin and thiazides are secreted by renal tubular organic anion transport, so thiazides could slightly reduce penicillin clearance. The effect is small and rarely matters clinically.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Penicillin vk?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally required.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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