Drug interactions
Hydrochlorothiazide-olmesartan + Pirbuterol
Severity: Moderate
Hydrochlorothiazide-olmesartan and Pirbuterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pirbuterol, a beta-2 agonist, can lower serum potassium and thiazides also do so. The additive effect may cause hypokalemia and arrhythmia risk, particularly at high doses.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 mediated cellular potassium uptake combined with thiazide renal potassium loss.
What to do
Monitor serum potassium in patients using frequent or high doses of pirbuterol. Replace potassium if low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Pirbuterol?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pirbuterol, a beta-2 agonist, can lower serum potassium and thiazides also do so. The additive effect may cause hypokalemia and arrhythmia risk, particularly at high doses.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Pirbuterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients using frequent or high doses of pirbuterol. Replace potassium if low.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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