Drug interactions
Hydrochlorothiazide-olmesartan + Potassium citrate / citric acid
Severity: Moderate
Hydrochlorothiazide-olmesartan and Potassium citrate / citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olmesartan reduces aldosterone-mediated potassium excretion, and added potassium can cause hyperkalemia, particularly in renal impairment or diabetes. Hydrochlorothiazide partly offsets this by increasing potassium loss, but the risk persists.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Potassium citrate / citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Angiotensin receptor blockade reduces renal potassium excretion, adding to the potassium load.
What to do
Check serum potassium and renal function at baseline and periodically. Reduce or stop the potassium supplement if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Potassium citrate / citric acid?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Potassium citrate / citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olmesartan reduces aldosterone-mediated potassium excretion, and added potassium can cause hyperkalemia, particularly in renal impairment or diabetes. Hydrochlorothiazide partly offsets this by increasing potassium loss, but the risk persists.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Potassium citrate / citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function at baseline and periodically. Reduce or stop the potassium supplement if potassium rises.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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