Drug interactions
Hydrochlorothiazide-olmesartan + Propranolol
Severity: Minor
Hydrochlorothiazide-olmesartan and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a beta-blocker with an ARB and thiazide gives additive blood pressure lowering, which is often intended but can cause hypotension or bradycardia. Beta-blockers can modestly raise potassium, and the thiazide may lower it. Thiazides and beta-blockers may also worsen glucose and lipid control.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic antihypertensive effects with minor opposing effects on potassium.
What to do
Monitor blood pressure, heart rate and serum potassium when starting or adjusting doses. In diabetic patients, watch glucose control.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Propranolol?
MediHelp rates the interaction as minor. Hydrochlorothiazide-olmesartan and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Combining a beta-blocker with an ARB and thiazide gives additive blood pressure lowering, which is often intended but can cause hypotension or bradycardia. Beta-blockers can modestly raise potassium, and the thiazide may lower it. Thiazides and beta-blockers may also worsen glucose and lipid control.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and serum potassium when starting or adjusting doses. In diabetic patients, watch glucose control.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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