Drug interactions
Hydrochlorothiazide-olmesartan + Sacubitril / valsartan
Severity: Major
Hydrochlorothiazide-olmesartan and Sacubitril / valsartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining olmesartan with valsartan-containing sacubitril/valsartan duplicates angiotensin receptor blockade. This increases the risk of hypotension, hyperkalemia and renal dysfunction without clear benefit.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Sacubitril / valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Dual ARB therapy gives excessive angiotensin II type 1 receptor blockade.
What to do
Avoid combining the two; stop olmesartan when sacubitril/valsartan is started. If combined, monitor potassium, creatinine and blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Sacubitril / valsartan?
MediHelp rates the interaction as major. Hydrochlorothiazide-olmesartan and Sacubitril / valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining olmesartan with valsartan-containing sacubitril/valsartan duplicates angiotensin receptor blockade. This increases the risk of hypotension, hyperkalemia and renal dysfunction without clear benefit.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Sacubitril / valsartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining the two; stop olmesartan when sacubitril/valsartan is started. If combined, monitor potassium, creatinine and blood pressure closely.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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