Drug interactions
Hydrochlorothiazide-olmesartan + Salicylates
Severity: Moderate
Hydrochlorothiazide-olmesartan and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates have a weaker effect on renal prostaglandins than other NSAIDs but may still reduce antihypertensive effect and impair kidney function with an ARB and diuretic. This is most relevant at high doses or in volume depletion.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal perfusion and causes sodium retention.
What to do
Monitor renal function, potassium and blood pressure, especially with high doses or volume depletion. Ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Salicylates?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-acetylated salicylates have a weaker effect on renal prostaglandins than other NSAIDs but may still reduce antihypertensive effect and impair kidney function with an ARB and diuretic. This is most relevant at high doses or in volume depletion.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, potassium and blood pressure, especially with high doses or volume depletion. Ensure adequate hydration.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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