Drug interactions
Hydrochlorothiazide-olmesartan + Salsalate
Severity: Moderate
Hydrochlorothiazide-olmesartan and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is an NSAID-type salicylate that may reduce the antihypertensive effect of olmesartan and hydrochlorothiazide. Together with an ARB and diuretic it raises the risk of acute kidney injury and hyperkalemia, especially in elderly or volume-depleted patients.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces glomerular perfusion and promotes sodium retention.
What to do
Keep patients hydrated and monitor blood pressure, creatinine and potassium. Use the lowest effective salsalate dose or choose an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Salsalate?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is an NSAID-type salicylate that may reduce the antihypertensive effect of olmesartan and hydrochlorothiazide. Together with an ARB and diuretic it raises the risk of acute kidney injury and hyperkalemia, especially in elderly or volume-depleted patients.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep patients hydrated and monitor blood pressure, creatinine and potassium. Use the lowest effective salsalate dose or choose an alternative analgesic.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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