Drug interactions
Hydrochlorothiazide-olmesartan + Shark cartilage
Severity: Minor
Hydrochlorothiazide-olmesartan and Shark cartilage: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Shark cartilage contains calcium and has been reported to cause hypercalcemia. Thiazides reduce urinary calcium excretion, so the combination could theoretically raise calcium.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Shark cartilage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Calcium load combined with thiazide-reduced renal calcium excretion.
What to do
Check serum calcium if the combination is used long term. Stop shark cartilage if hypercalcemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Shark cartilage?
MediHelp rates the interaction as minor. Hydrochlorothiazide-olmesartan and Shark cartilage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Shark cartilage contains calcium and has been reported to cause hypercalcemia. Thiazides reduce urinary calcium excretion, so the combination could theoretically raise calcium.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Shark cartilage?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum calcium if the combination is used long term. Stop shark cartilage if hypercalcemia occurs.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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