Drug interactions
Hydrochlorothiazide-olmesartan + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Moderate
Hydrochlorothiazide-olmesartan and Sodium sulfate / ?magnesium sulfate / potassium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osmotic bowel preparations cause fluid loss and electrolyte shifts. In patients taking a thiazide diuretic and an angiotensin receptor blocker, volume depletion and electrolyte disturbance can be amplified, raising the risk of arrhythmia, seizures and acute kidney injury.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive fluid and electrolyte depletion from bowel-prep diarrhea plus diuretic-induced natriuresis and ARB-dependent reduction in renal perfusion autoregulation.
What to do
Ensure adequate hydration and consider holding the diuretic and olmesartan on the day of bowel preparation. Check electrolytes and renal function in high-risk patients such as the elderly or those with kidney disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osmotic bowel preparations cause fluid loss and electrolyte shifts. In patients taking a thiazide diuretic and an angiotensin receptor blocker, volume depletion and electrolyte disturbance can be amplified, raising the risk of arrhythmia, seizures and acute kidney injury.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and consider holding the diuretic and olmesartan on the day of bowel preparation. Check electrolytes and renal function in high-risk patients such as the elderly or those with kidney disease.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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