Drug interactions
Hydrochlorothiazide-olmesartan + Sofosbuvir / velpatasvir
Severity: Minor
Hydrochlorothiazide-olmesartan and Sofosbuvir / velpatasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits hepatic and intestinal OATP transporters, and olmesartan is an OATP1B1/1B3 substrate. Olmesartan exposure may rise modestly, increasing the potential for hypotension or renal effects.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Sofosbuvir / velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Velpatasvir inhibition of OATP1B1, OATP1B3 and OATP2B1 reduces olmesartan uptake and clearance.
What to do
No empiric dose change is needed. Monitor blood pressure and renal function when starting or stopping therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as minor. Hydrochlorothiazide-olmesartan and Sofosbuvir / velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Velpatasvir inhibits hepatic and intestinal OATP transporters, and olmesartan is an OATP1B1/1B3 substrate. Olmesartan exposure may rise modestly, increasing the potential for hypotension or renal effects.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Sofosbuvir / velpatasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed. Monitor blood pressure and renal function when starting or stopping therapy.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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