Drug interactions
Hydrochlorothiazide-olmesartan + Sulfasalazine
Severity: Minor
Hydrochlorothiazide-olmesartan and Sulfasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine can occasionally impair renal function, and olmesartan can reduce glomerular filtration in susceptible patients, so combined use may worsen kidney function especially with volume depletion. Potassium effects are not well established with sulfasalazine, so the main concern is renal.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive renal effects; no well-established pharmacokinetic or potassium-related mechanism.
What to do
Monitor renal function and serum potassium periodically, particularly in elderly or volume-depleted patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Sulfasalazine?
MediHelp rates the interaction as minor. Hydrochlorothiazide-olmesartan and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfasalazine can occasionally impair renal function, and olmesartan can reduce glomerular filtration in susceptible patients, so combined use may worsen kidney function especially with volume depletion. Potassium effects are not well established with sulfasalazine, so the main concern is renal.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Sulfasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and serum potassium periodically, particularly in elderly or volume-depleted patients.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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