Drug interactions
Hydrochlorothiazide-olmesartan + Synthetic human angiotensin ii
Severity: Moderate
Hydrochlorothiazide-olmesartan and Synthetic human angiotensin ii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olmesartan blocks the AT1 receptor through which angiotensin II acts, so the pressor effect of exogenous angiotensin II may be reduced. This could blunt the response in patients with vasodilatory shock who are on an ARB.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism at the angiotensin II type 1 receptor.
What to do
Anticipate higher angiotensin II dose requirements in patients recently taking olmesartan and titrate to blood pressure response. Consider other vasopressors if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Synthetic human angiotensin ii?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olmesartan blocks the AT1 receptor through which angiotensin II acts, so the pressor effect of exogenous angiotensin II may be reduced. This could blunt the response in patients with vasodilatory shock who are on an ARB.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Synthetic human angiotensin ii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Anticipate higher angiotensin II dose requirements in patients recently taking olmesartan and titrate to blood pressure response. Consider other vasopressors if the response is inadequate.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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