Drug interactions
Hydrochlorothiazide-olmesartan + Terbutaline
Severity: Moderate
Hydrochlorothiazide-olmesartan and Terbutaline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide and terbutaline can both lower serum potassium, which may lead to clinically relevant hypokalemia and arrhythmias, especially with systemic or high-dose use. Olmesartan partly counteracts the effect.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Terbutaline belongs to Respiratory.
Why it happens
Additive hypokalemia from thiazide renal potassium loss and beta-2 agonist intracellular potassium shift.
What to do
Monitor serum potassium, particularly with systemic terbutaline or acute asthma. Correct hypokalemia and monitor magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Terbutaline
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Terbutaline?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide and terbutaline can both lower serum potassium, which may lead to clinically relevant hypokalemia and arrhythmias, especially with systemic or high-dose use. Olmesartan partly counteracts the effect.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Terbutaline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, particularly with systemic terbutaline or acute asthma. Correct hypokalemia and monitor magnesium.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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