Drug interactions
Hydrochlorothiazide-olmesartan + Ticarcillin
Severity: Moderate
Hydrochlorothiazide-olmesartan and Ticarcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticarcillin is given with a large sodium load and can cause hypokalemia, which may add to thiazide-induced potassium loss. Competition for tubular secretion may also slightly raise levels of either drug.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Ticarcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal potassium wasting and possible competition for renal tubular secretion.
What to do
Monitor serum potassium and renal function during ticarcillin therapy and replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Ticarcillin?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Ticarcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticarcillin is given with a large sodium load and can cause hypokalemia, which may add to thiazide-induced potassium loss. Competition for tubular secretion may also slightly raise levels of either drug.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Ticarcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function during ticarcillin therapy and replace potassium as needed.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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