Drug interactions
Hydrochlorothiazide-olmesartan + Trilostane
Severity: Moderate
Hydrochlorothiazide-olmesartan and Trilostane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trilostane inhibits adrenal steroid synthesis including aldosterone, which reduces potassium excretion. With olmesartan it may increase hyperkalemia risk, and it adds to the natriuretic effect and blood pressure lowering of the thiazide.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Trilostane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of 3-beta-hydroxysteroid dehydrogenase lowers aldosterone, adding to angiotensin receptor blockade and altering thiazide potassium effects.
What to do
Monitor serum potassium, sodium and blood pressure when combined, especially in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Trilostane?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Trilostane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trilostane inhibits adrenal steroid synthesis including aldosterone, which reduces potassium excretion. With olmesartan it may increase hyperkalemia risk, and it adds to the natriuretic effect and blood pressure lowering of the thiazide.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Trilostane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, sodium and blood pressure when combined, especially in renal impairment.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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