Drug interactions
Hydrochlorothiazide-olmesartan + Vilanterol / fluticasone furoate inhaled
Severity: Minor
Hydrochlorothiazide-olmesartan and Vilanterol / fluticasone furoate inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a beta-agonist, can lower serum potassium and may add to the hypokalemia caused by hydrochlorothiazide. This may promote ECG changes or arrhythmias, mainly at high doses of the beta-agonist.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Vilanterol / fluticasone furoate inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Beta-2 stimulation shifts potassium into cells, adding to thiazide-induced renal potassium loss.
What to do
Monitor serum potassium in patients at risk, such as those with heart disease or on high doses. Correct hypokalemia and avoid exceeding recommended inhaler doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as minor. Hydrochlorothiazide-olmesartan and Vilanterol / fluticasone furoate inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vilanterol, a beta-agonist, can lower serum potassium and may add to the hypokalemia caused by hydrochlorothiazide. This may promote ECG changes or arrhythmias, mainly at high doses of the beta-agonist.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients at risk, such as those with heart disease or on high doses. Correct hypokalemia and avoid exceeding recommended inhaler doses.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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