Drug interactions
Hydrochlorothiazide-olmesartan + Willow bark
Severity: Minor
Hydrochlorothiazide-olmesartan and Willow bark: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Willow bark contains salicin, which is converted to salicylic acid. Salicylates compete with thiazides for tubular secretion and NSAID-like effects may blunt antihypertensive and diuretic effects, though the effect with willow bark appears small.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Willow bark have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular anionic secretion and possible prostaglandin inhibition by salicylates.
What to do
Monitor blood pressure and renal function if willow bark is used regularly, particularly in older or volume-depleted patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Willow bark?
MediHelp rates the interaction as minor. Hydrochlorothiazide-olmesartan and Willow bark have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Willow bark contains salicin, which is converted to salicylic acid. Salicylates compete with thiazides for tubular secretion and NSAID-like effects may blunt antihypertensive and diuretic effects, though the effect with willow bark appears small.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Willow bark?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function if willow bark is used regularly, particularly in older or volume-depleted patients.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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