Drug interactions
Hydrochlorothiazide-olmesartan + Xipamide
Severity: Moderate
Hydrochlorothiazide-olmesartan and Xipamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xipamide is a thiazide-like diuretic, so combining it with hydrochlorothiazide duplicates therapy and increases diuresis. This can cause hypotension, hyponatremia, hypokalemia and renal impairment, and olmesartan adds to the blood pressure and renal effects.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of distal tubular sodium chloride reabsorption together with ARB-related blood pressure lowering.
What to do
Avoid duplicating thiazide-type diuretics unless intended, and monitor electrolytes, renal function and blood pressure if combined.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Xipamide?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Xipamide is a thiazide-like diuretic, so combining it with hydrochlorothiazide duplicates therapy and increases diuresis. This can cause hypotension, hyponatremia, hypokalemia and renal impairment, and olmesartan adds to the blood pressure and renal effects.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Xipamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicating thiazide-type diuretics unless intended, and monitor electrolytes, renal function and blood pressure if combined.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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