Drug interactions
Hydrocortisone + Hydroxyprogesterone caproate
Severity: Minor
Hydrocortisone and Hydroxyprogesterone caproate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyprogesterone caproate is metabolized in part by CYP3A4. Hydrocortisone is not a significant CYP3A4 inducer at usual doses, so no meaningful drop in progestin levels is expected.
What this interaction means in plain words
Hydrocortisone and Hydroxyprogesterone caproate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical weak CYP3A4 induction by hydrocortisone; no established pharmacokinetic effect.
What to do
No action is needed beyond routine clinical monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Hydroxyprogesterone caproate?
MediHelp rates the interaction as minor. Hydrocortisone and Hydroxyprogesterone caproate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydroxyprogesterone caproate is metabolized in part by CYP3A4. Hydrocortisone is not a significant CYP3A4 inducer at usual doses, so no meaningful drop in progestin levels is expected.
How serious is the interaction between Hydrocortisone and Hydroxyprogesterone caproate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed beyond routine clinical monitoring.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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