Drug interactions
Hydrocortisone + Indacaterol inhaled
Severity: Moderate
Hydrocortisone and Indacaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both beta-2 agonists and corticosteroids can lower serum potassium. Together they may add to hypokalemia, particularly with high steroid doses, in patients with other potassium-wasting drugs, or with hypoxia.
What this interaction means in plain words
Hydrocortisone and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive potassium lowering through beta-2 stimulated intracellular shift and mineralocorticoid-mediated renal potassium loss.
What to do
Monitor serum potassium in patients on systemic hydrocortisone, especially with other hypokalemic drugs. Replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Indacaterol inhaled?
MediHelp rates the interaction as moderate. Hydrocortisone and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both beta-2 agonists and corticosteroids can lower serum potassium. Together they may add to hypokalemia, particularly with high steroid doses, in patients with other potassium-wasting drugs, or with hypoxia.
How serious is the interaction between Hydrocortisone and Indacaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients on systemic hydrocortisone, especially with other hypokalemic drugs. Replace potassium as needed.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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