Drug interactions
Hydrocortisone + Indapamide
Severity: Moderate
Hydrocortisone and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower serum potassium, so using them together raises the chance of clinically relevant hypokalemia. This matters most with prolonged or high-dose corticosteroid therapy and in patients with heart disease or on other QT-prolonging drugs.
What this interaction means in plain words
Hydrocortisone and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Indapamide belongs to Cardiovascular.
Why it happens
Additive potassium loss: corticosteroid mineralocorticoid effect increases renal potassium excretion alongside thiazide-like diuretic kaliuresis.
What to do
Monitor serum potassium and magnesium periodically, especially at the start of therapy or with dose changes. Give potassium supplementation if hypokalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Indapamide
Frequently asked questions
Can I take Hydrocortisone with Indapamide?
MediHelp rates the interaction as moderate. Hydrocortisone and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower serum potassium, so using them together raises the chance of clinically relevant hypokalemia. This matters most with prolonged or high-dose corticosteroid therapy and in patients with heart disease or on other QT-prolonging drugs.
How serious is the interaction between Hydrocortisone and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium periodically, especially at the start of therapy or with dose changes. Give potassium supplementation if hypokalemia develops.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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