Drug interactions
Hydrocortisone + Influenza virus vaccine quadrivalent recombinant
Severity: Minor
Hydrocortisone and Influenza virus vaccine quadrivalent recombinant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids at immunosuppressive doses may reduce antibody response to recombinant influenza vaccine. Physiologic replacement doses have little effect.
What this interaction means in plain words
Hydrocortisone and Influenza virus vaccine quadrivalent recombinant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Glucocorticoid-mediated immunosuppression dampens vaccine-induced antibody responses.
What to do
Give the annual influenza vaccine as scheduled; it is not live and is safe with steroids. Do not delay vaccination for steroid therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Influenza virus vaccine quadrivalent recombinant?
MediHelp rates the interaction as minor. Hydrocortisone and Influenza virus vaccine quadrivalent recombinant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic corticosteroids at immunosuppressive doses may reduce antibody response to recombinant influenza vaccine. Physiologic replacement doses have little effect.
How serious is the interaction between Hydrocortisone and Influenza virus vaccine quadrivalent recombinant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the annual influenza vaccine as scheduled; it is not live and is safe with steroids. Do not delay vaccination for steroid therapy.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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