Drug interactions
Hydrocortisone + Insulin neutral human
Severity: Moderate
Hydrocortisone and Insulin neutral human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone raises blood glucose and increases insulin requirements, particularly at supraphysiologic doses. Control may worsen after starting or increasing the steroid.
What this interaction means in plain words
Hydrocortisone and Insulin neutral human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Insulin neutral human belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through glucocorticoid-induced insulin resistance and increased hepatic gluconeogenesis.
What to do
Monitor glucose closely and raise insulin as required while on therapy. Lower insulin when the steroid is reduced or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin neutral human
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Insulin neutral human?
MediHelp rates the interaction as moderate. Hydrocortisone and Insulin neutral human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrocortisone raises blood glucose and increases insulin requirements, particularly at supraphysiologic doses. Control may worsen after starting or increasing the steroid.
How serious is the interaction between Hydrocortisone and Insulin neutral human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely and raise insulin as required while on therapy. Lower insulin when the steroid is reduced or stopped.
What other medicines interact with Insulin neutral human?
MediHelp also lists interactions of Insulin neutral human with, for example, Chlorpropamide, Ethanol, Mecasermin. The full list is on the Insulin neutral human page.
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