Drug interactions
Hydrocortisone + Isoniazid
Severity: Minor
Hydrocortisone and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid may inhibit CYP3A4 modestly and could slightly increase hydrocortisone exposure. Corticosteroids may also alter isoniazid acetylation, but there is no well-established clinically significant interaction.
What this interaction means in plain words
Hydrocortisone and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocortisone belongs to Endocrine; Isoniazid belongs to Anti Bacterial.
Why it happens
Possible weak CYP3A4 inhibition by isoniazid; not well established.
What to do
No routine adjustment is needed; monitor for signs of corticosteroid excess during prolonged co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Isoniazid
Frequently asked questions
Can I take Hydrocortisone with Isoniazid?
MediHelp rates the interaction as minor. Hydrocortisone and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid may inhibit CYP3A4 modestly and could slightly increase hydrocortisone exposure. Corticosteroids may also alter isoniazid acetylation, but there is no well-established clinically significant interaction.
How serious is the interaction between Hydrocortisone and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for signs of corticosteroid excess during prolonged co-therapy.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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