Drug interactions
Hydrocortisone + Ixabepilone
Severity: Minor
Hydrocortisone and Ixabepilone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ixabepilone is a CYP3A4 substrate, but hydrocortisone is not a meaningful CYP3A4 inducer at usual doses. A clinically important fall in ixabepilone exposure is unlikely.
What this interaction means in plain words
Hydrocortisone and Ixabepilone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical weak CYP3A4 induction by hydrocortisone; no established pharmacokinetic effect.
What to do
No adjustment is needed. Hydrocortisone is commonly given as hypersensitivity premedication with ixabepilone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Ixabepilone?
MediHelp rates the interaction as minor. Hydrocortisone and Ixabepilone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ixabepilone is a CYP3A4 substrate, but hydrocortisone is not a meaningful CYP3A4 inducer at usual doses. A clinically important fall in ixabepilone exposure is unlikely.
How serious is the interaction between Hydrocortisone and Ixabepilone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed. Hydrocortisone is commonly given as hypersensitivity premedication with ixabepilone.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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