Drug interactions
Hydrocortisone + Lacidipine
Severity: Minor
Hydrocortisone and Lacidipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone may weakly induce CYP3A4 and slightly lower lacidipine levels, which could blunt its antihypertensive effect. A clinically significant change is not expected at usual doses.
What this interaction means in plain words
Hydrocortisone and Lacidipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocortisone belongs to Endocrine; Lacidipine belongs to Cardiovascular.
Why it happens
Possible weak CYP3A4 induction by hydrocortisone increasing lacidipine metabolism.
What to do
Monitor blood pressure when starting or stopping high-dose hydrocortisone and adjust lacidipine if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Lacidipine?
MediHelp rates the interaction as minor. Hydrocortisone and Lacidipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrocortisone may weakly induce CYP3A4 and slightly lower lacidipine levels, which could blunt its antihypertensive effect. A clinically significant change is not expected at usual doses.
How serious is the interaction between Hydrocortisone and Lacidipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or stopping high-dose hydrocortisone and adjust lacidipine if needed.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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