Drug interactions
Hydrocortisone + Lepirudin
Severity: Moderate
Hydrocortisone and Lepirudin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids may alter coagulation and affect vascular integrity, and GI ulceration risk adds to the bleeding risk with a direct thrombin inhibitor. Effects on anticoagulation are inconsistent.
What this interaction means in plain words
Hydrocortisone and Lepirudin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mixed pharmacodynamic effects on coagulation and mucosal integrity; additive bleeding risk with a direct thrombin inhibitor.
What to do
Monitor aPTT and watch for bleeding, including gastrointestinal bleeding, during combined therapy. Adjust lepirudin per aPTT.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Lepirudin?
MediHelp rates the interaction as moderate. Hydrocortisone and Lepirudin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids may alter coagulation and affect vascular integrity, and GI ulceration risk adds to the bleeding risk with a direct thrombin inhibitor. Effects on anticoagulation are inconsistent.
How serious is the interaction between Hydrocortisone and Lepirudin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor aPTT and watch for bleeding, including gastrointestinal bleeding, during combined therapy. Adjust lepirudin per aPTT.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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