Drug interactions
Hydrocortisone + Lercanidipine
Severity: Minor
Hydrocortisone and Lercanidipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone may weakly induce CYP3A4 and modestly reduce lercanidipine concentrations, potentially weakening blood pressure lowering. The effect is expected to be small at usual doses.
What this interaction means in plain words
Hydrocortisone and Lercanidipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocortisone belongs to Endocrine; Lercanidipine belongs to Cardiovascular.
Why it happens
Possible weak CYP3A4 induction by hydrocortisone increasing lercanidipine metabolism.
What to do
Monitor blood pressure when hydrocortisone is started or stopped and adjust lercanidipine if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrocortisone and Lercanidipine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Lercanidipine?
MediHelp rates the interaction as minor. Hydrocortisone and Lercanidipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrocortisone may weakly induce CYP3A4 and modestly reduce lercanidipine concentrations, potentially weakening blood pressure lowering. The effect is expected to be small at usual doses.
How serious is the interaction between Hydrocortisone and Lercanidipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when hydrocortisone is started or stopped and adjust lercanidipine if control changes.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
