Drug interactions
Hydrocortisone + Lonapegsomatropin
Severity: Moderate
Hydrocortisone and Lonapegsomatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone inhibits 11-beta-hydroxysteroid dehydrogenase type 1, which regenerates active cortisol from cortisone. Starting lonapegsomatropin can therefore lower cortisol exposure and unmask adrenal insufficiency in patients on replacement therapy. Patients on hydrocortisone replacement may need higher doses.
What this interaction means in plain words
Hydrocortisone and Lonapegsomatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Lonapegsomatropin belongs to Endocrine.
Why it happens
Growth hormone inhibits 11-beta-HSD1, reducing conversion of cortisone to active cortisol.
What to do
Monitor for symptoms of adrenal insufficiency after starting lonapegsomatropin and increase the hydrocortisone maintenance or stress dose when needed. Reassess adrenal function periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Lonapegsomatropin
Frequently asked questions
Can I take Hydrocortisone with Lonapegsomatropin?
MediHelp rates the interaction as moderate. Hydrocortisone and Lonapegsomatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone inhibits 11-beta-hydroxysteroid dehydrogenase type 1, which regenerates active cortisol from cortisone. Starting lonapegsomatropin can therefore lower cortisol exposure and unmask adrenal insufficiency in patients on replacement therapy. Patients on hydrocortisone replacement may need higher doses.
How serious is the interaction between Hydrocortisone and Lonapegsomatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for symptoms of adrenal insufficiency after starting lonapegsomatropin and increase the hydrocortisone maintenance or stress dose when needed. Reassess adrenal function periodically.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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