Drug interactions
Hydrocortisone + Metformin-sitagliptin
Severity: Moderate
Hydrocortisone and Metformin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic hydrocortisone can raise blood glucose and reduce the effectiveness of antidiabetic therapy, especially at higher doses or with prolonged use.
What this interaction means in plain words
Hydrocortisone and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Glucocorticoids increase hepatic gluconeogenesis and insulin resistance, opposing the antidiabetic drugs.
What to do
Monitor blood glucose during systemic hydrocortisone therapy and adjust antidiabetic doses as needed, reassessing when the steroid is tapered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Metformin-sitagliptin?
MediHelp rates the interaction as moderate. Hydrocortisone and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic hydrocortisone can raise blood glucose and reduce the effectiveness of antidiabetic therapy, especially at higher doses or with prolonged use.
How serious is the interaction between Hydrocortisone and Metformin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during systemic hydrocortisone therapy and adjust antidiabetic doses as needed, reassessing when the steroid is tapered.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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