Drug interactions
Hydrocortisone + Methyltestosterone
Severity: Moderate
Hydrocortisone and Methyltestosterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both corticosteroids and androgens promote sodium and fluid retention, so edema may be aggravated when combined. Patients with heart, liver or kidney disease are most at risk.
What this interaction means in plain words
Hydrocortisone and Methyltestosterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sodium and water retention from corticosteroid and androgenic effects.
What to do
Monitor weight, blood pressure and edema, and adjust diuretic therapy if fluid accumulates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Methyltestosterone?
MediHelp rates the interaction as moderate. Hydrocortisone and Methyltestosterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both corticosteroids and androgens promote sodium and fluid retention, so edema may be aggravated when combined. Patients with heart, liver or kidney disease are most at risk.
How serious is the interaction between Hydrocortisone and Methyltestosterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor weight, blood pressure and edema, and adjust diuretic therapy if fluid accumulates.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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