Drug interactions
Hydrocortisone + Nitrendipine
Severity: Minor
Hydrocortisone and Nitrendipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitrendipine is cleared by CYP3A4, and hydrocortisone may weakly induce this enzyme. A small fall in nitrendipine exposure is possible but rarely significant.
What this interaction means in plain words
Hydrocortisone and Nitrendipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 induction by hydrocortisone increasing nitrendipine metabolism.
What to do
No routine adjustment; monitor blood pressure if high-dose steroids are started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Nitrendipine?
MediHelp rates the interaction as minor. Hydrocortisone and Nitrendipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nitrendipine is cleared by CYP3A4, and hydrocortisone may weakly induce this enzyme. A small fall in nitrendipine exposure is possible but rarely significant.
How serious is the interaction between Hydrocortisone and Nitrendipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor blood pressure if high-dose steroids are started.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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