Drug interactions
Hydrocortisone + Olodaterol inhaled
Severity: Moderate
Hydrocortisone and Olodaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower serum potassium, and their combination may cause hypokalemia. This is more relevant at high corticosteroid doses or in patients with cardiac disease, where low potassium raises arrhythmia risk.
What this interaction means in plain words
Hydrocortisone and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from beta-2 agonist intracellular potassium shift and corticosteroid mineralocorticoid-mediated renal potassium loss.
What to do
Monitor serum potassium in patients on high doses, with cardiac disease, or on other potassium-lowering drugs, and replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Olodaterol inhaled?
MediHelp rates the interaction as moderate. Hydrocortisone and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower serum potassium, and their combination may cause hypokalemia. This is more relevant at high corticosteroid doses or in patients with cardiac disease, where low potassium raises arrhythmia risk.
How serious is the interaction between Hydrocortisone and Olodaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients on high doses, with cardiac disease, or on other potassium-lowering drugs, and replace potassium as needed.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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