Drug interactions
Hydrocortisone + Parecoxib
Severity: Moderate
Hydrocortisone and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib, a COX-2 inhibitor, combined with systemic corticosteroids may increase the risk of gastrointestinal ulceration and bleeding. COX-2 selectivity reduces but does not remove the additive risk.
What this interaction means in plain words
Hydrocortisone and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastrointestinal mucosal injury from NSAID effects and corticosteroid impairment of mucosal healing.
What to do
Use the shortest effective duration and consider gastroprotection with a proton pump inhibitor in patients at risk. Monitor for gastrointestinal bleeding symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Parecoxib?
MediHelp rates the interaction as moderate. Hydrocortisone and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parecoxib, a COX-2 inhibitor, combined with systemic corticosteroids may increase the risk of gastrointestinal ulceration and bleeding. COX-2 selectivity reduces but does not remove the additive risk.
How serious is the interaction between Hydrocortisone and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the shortest effective duration and consider gastroprotection with a proton pump inhibitor in patients at risk. Monitor for gastrointestinal bleeding symptoms.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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